Sulfhydryl groups as targets of mercury toxicity
نویسندگان
چکیده
منابع مشابه
Synaptic cysteine sulfhydryl groups as targets of electrophilic neurotoxicants.
Many structurally diverse chemicals (e.g., acrylamide, 2,4-dithiobiuret, methylmercury) are electrophiles and cause synaptic dysfunction by unknown mechanisms. The purpose of this Forum review is to discuss the possibility that highly nucleophilic cysteine thiolate groups within catalytic triads of synaptic proteins represent specific and necessary targets for electrophilic neurotoxicants. Most...
متن کاملREVIEW Synaptic Cysteine Sulfhydryl Groups as Targets of Electrophilic Neurotoxicants
Many structurally diverse chemicals (e.g., acrylamide, 2,4dithiobiuret, methylmercury) are electrophiles and cause synaptic dysfunction by unknown mechanisms. The purpose of this Forum review is to discuss the possibility that highly nucleophilic cysteine thiolate groups within catalytic triads of synaptic proteins represent specific and necessary targets for electrophilic neurotoxicants. Most ...
متن کاملMercury toxicity
Mercury is a metal found in elemental, organic, and inorganic forms in the nature. This substance is present in the composition of earth crust, soil, air, and even in some tissues of plants and sea animals. Each year nearly 3400 tons of mercury compounds are released in the environment, which 95% settle in the soil, 3% in the oceans, and 2% in the atmosphere. Different industrial products li...
متن کاملThe reaction of methyl mercury nitrate with the sulfhydryl groups of yeast glyceraldehyde-3-phosphate dehydrogenase.
The importance of two of the thiol groups of yeast triosephosphate dehydrogenase for its activity haa been shown by the abolition of activity and diphosphopyridine nucleotide binding by the addition of 2 equivalents of p-chloromercuribenzoate (PCMB) (1, 2). The reaction of methyl mercury nitrate with this enzyme has been found to be anomalous in the sense that this mercury compound, unlike PCMB...
متن کاملSulfhydryl Groups in Proteins
Egg albumin in the native, unaltered state, does not give tests characteristic of sulfhydryl groups. When, however, this protein is treated in any one of several ways, such as by heat (8, 9, 17), ultraviolet irradiation (lo), shaking (lo), or by solution in urea or other amides (7), free sulfhydryl groups make their appearance. The amount of free -SH groups appearing in egg albumin through the ...
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ژورنال
عنوان ژورنال: Coordination Chemistry Reviews
سال: 2020
ISSN: 0010-8545
DOI: 10.1016/j.ccr.2020.213343